Cleaning Validation
Cleaning Validation and Verification with Sievers TOC
Increase efficiency, process understanding, and confidence throughout the lifecycle of your cleaning validation or verification program. TOC analysis is a fast and simple analytical method for detecting low levels of organic compounds and allows for detection of degradants and contamination not possible via HPLC. Compared to specific methods such as HPLC, TOC offers simpler method development and allows you to test not only for product removal, but also removal of excipients, degradants, and cleaning agents.
Accurately measure organics in samples without background interference
Sievers TOC Analyzers use our unique membrane conductometric technology to accurately measure organics in rinse and online samples without interference from background substances. We help make method development and running cleaning samples as simple as possible. You can use the Autoreagent feature to ensure complete oxidation when the TOC concentration of your sample is not known, and our timetested technology ensures superior sensitivity and recovery.
Sievers TOC Analyzers for Cleaning Validation
Total organic carbon (TOC) analysis is a simple and highly effective tool for cleaning validation, verification, and process control in industries such as pharmaceuticals, cosmetics, food & beverage, and medical devices. Using TOC for cleaning verification ultimately enables companies to operate more efficiently, reduce risks, and improve quality control.
Testing can occur in the lab, on the manufacturing floor (at-line), or in a slip stream from the final rinse (online) of an automated cleaning cycle (attached to CIP skid). With Sievers M9 Lab, Portable, and On-Line TOC Analyzers, you can design your cleaning program around your manufacturing processes and needs. Develop methods faster with Autoreagent mode, and decrease analysis time from two minutes to four seconds with Turbo mode.